The purpose of this research was to evaluate vascular function after a high fat meal challenge. Fifteen overweight males were randomized to either a peanut meal containing 3 oz of ground peanuts (as a shake) or a control meal (a shake without peanuts) that were matched for energy and macronutrients. The lipid profile, glucose, and insulin were measured five times after each meal. Flow-mediated dilatation (FMD) was measured to assess vascular function.
The researchers found that the control meal decreased FMD by 1.2% compared to baseline. In contrast, there was no decrease in FMD after the peanut meal. These results demonstrate that the peanut meal maintained normal vascular function whereas the high fat-matched control meal impaired vascular function acutely.
Typically after a high fat meal, vascular function is reduced, albeit temporarily, until the fat that is in the blood (from the meal) is cleared. Strategies that can blunt this response to both dietary fat and its effect on vascular dysfunction may decrease the risk of coronary disease.
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